SCHOOL OF NATURAL SCIENCES AND MEDICINE
ILIA STATE UNIVERSITY

Full Professor in Biochemistry of School of Natural Sciences and Engineering, Doctor of Biological

Director of Institute of Chemical





In 1971 year he graduated from Iv.Javakhishvili Tbilisi State University with degree in Biochemistry, in 1974 year he finished PhD program of „Human and Animal Biochemistry“ in Moscow State University. PhD (candidate) dissertation in Biochemistry was defensed in 1976, then in 1987 he obtained degree of Doctor of Biological Sciences in the field of Biochemistry. From 1974 works in Department of Biochemistry of I.Beritashvili Center of Experimental Biomedicine (former Institute of Physiology) at research scientist position, then from 1983 – as Head of Department. In 2006-2008 was Full Professor and Dean of Biology Faculty at Iv.Javakhishvili Tbilisi State University. From 2008 to present works at Ilia State University as Full Professor in the field of Biochemistry.  The main research area is metabolism of neural and immune systems, bioenergetics and mechanisms of action of biologically active compounds, molecular basis of neuro- and immunopathologies.  Research investigation is carrying out in the Institute of Chemical Biology of Ilia State

Scientific interests / research interests

  • Neurochemistry
  • Regulation of immune cells’ activity
  • Intracellular signaling systems
  • Mitochondrial metabolism
  • Neuroprotection and cytotoxicity
  • Mechanism of action of biologically active compounds
  • Mitochondrial dysfunctions
  • Neurodegenerative diseases
  • Immune disorders
  • Bioenergetics of tumor cells

  1. Jojua N., Sharikadze N., Zhuravliova E., Zaalishvili E., Mikeladze D.G. Nobiletin restores impaired hippocampal mitochondrial bioenergetics in hypothyroidism through activation of matrix substrate-level phosphorylation. Nutritional Neuroscience, 2015, 18(5):225-31
  2. Natsvlishvili N., Goguadze N., Zhuravliova E., Mikeladze D. Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria., BMC Biochemistry, 2015, 16:11
  3. Koriauli1 S, Barbakadze T, Natsvlishvili1,N, Dabrundashvili3 N, Kvaratskhelia E, Mikeladze DIL-10 Gene Knockout Reduces the Expression of mGlu Receptor 1a/b and Decreases the Glutamate-Dependent Production of Nitric Oxide. J. Biomedical Science and Engineering, 2014, 7, 1019-1029
  4. Barbakadze T, Natsvlishvili N, Mikeladze D. Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin avß3 receptor in undifferentiated and differentiated PC-12 cellsCell Biochemistry and Function.  2014, 32(3):282-6.
  5. Shanshiashvili LV, Kalandadze IV, Ramsden JJ, Mikeladze DG. Adhesive Properties and Inflammatory Potential of Citrullinated Myelin Basic Protein Peptide. .Neurochemical Research. 2012, 37, no 9:1959-1966.
  6. Bátor JVarga JBerta GBarbakadze TMikeladze DRamsden JSzeberényi JSodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein. Cell Molecular Biology Letters. 2012, (3): 323-332. 
  7. Shanshiashvili LV, Dabrundashvili N, Natsvlishvili N, Kvaratskhelia E, Zhuravliova E, Barbakadze T, Koriauli S, Maisuradze E, Topuria T, Mikeladze DG. mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes. Molecular Immunology.2012, 51(3-4):310-5
  8. E. Zhuravliova, T. Barbakadze, N. Jojua, E. Zaalishvili, L. Shanshiashvili, N. Natsvlishvili, I. Kalandadze, N. Narmania, I. Chogovadze, D. MikeladzeSynaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism. Cellular and Molecular Neurobiology (2012) 32:1311–1321
  9. Dabrundashvili N.G., Kvaratskhelia E., Gagua  M., Maisuradze E., Chkhikvishvili I., Zhuravliova E., Mikeladze D.G. Nobiletin Transiently Increases The Production Of Nitric Oxide And Changes The Activity Of Succinate Dehydrogenase In Human Blood Lymphocytes. Journal of Food Biochemistry, 2011, 35, 2, 638–649,
  10. L. Shanshiashvili,  N. Narmania,  T. Barbakadze, E. Zhuravliova,  N. Natsvlishvili,  J. Ramsden, D. G. Mikeladze S-Nitrosylation Decreases the Adsorption of H-Ras in Lipid Bilayer and Changes Intrinsic Catalytic Activity. Cell Biochemistry and Biophysics 2011;59(3):191-9
  11. Zhuravliova E, Barbakadze T, Zaalishvili E, Chipashvili M, Koshoridze N, Mikeladze D. Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase. Behavioural Brain Research. 2009;205(2):377-83
  12. Zhuravliova E, Barbakadze T, Narmania N, Sepashvili M, Mikeladze DG. Hypoinsulinemia alleviates the GRF1/Ras/Akt anti-apoptotic pathway and induces alterations of mitochondrial ras trafficking in neuronal cells. Neurochemical Research. 2009;34(6):1076-82.
  13. Kvaratskhelia E.,  Maisuradze E., Dabrundashvili NG, Natsvlishvili N, Zhuravliova E., Mikeladze DGN-Methyl-D-Aspartate and sigma-ligands change the production of Interleukins 8 and 10 in lymphocytes through modulation of the NMDA glutamate receptorNeuroimmunomodulation 2009;16:201-207
  14. Zhuravliova E, Barbakadze T, Natsvlishvili N, Mikeladze DG. Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity. Neurochemistry International. 2007, 50, 976–982
  15. Zhuravliova E, Barbakadze T, Narmania N. Ramsden J. Mikeladze DG. Inhibition of nitric oxide synthase and farnesyltransferase change the activities of several transcription factors. Journal of Molecular Neuroscience, 2007, 31, 3, 281-287.
  16. Sephashvili M, Zhuravliova E., Barbakadze T., Khundadze M, Narmania N, Mikeladze DG L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-rat pheochromocytoma cellsNeurochemical Research, 2006;31(10):1205-10.
  17. Barbakadze T., Zhuravliova E., Sepashvili M., Zaalishvili E., Ramsden JJ., Bator J., Szeberenyi J., Mikeladze D.  Production of homocysteine in serum-starved apoptotic PC12 cells depends on the activation and modification of Ras. Neuroscience Letters. 2005, 391, 1-2, 56-61, 2005.
  18. Rotas G, Natchkebia K, Natsvlishvili N, Kekelidze M, Varvounis G, Mikeladze D. Action of a novel pyrrolo[1,2-c][1,3]benzodiazepine on the viability of Jurkat and neuronal/glial cellsBioorganic Medicinal Chemical Letters, 15/13, 3220-3223, 2005.
  19. Zhuravliova E, Barbakadze T, Mikeladze D, Kekelidze T. Creatine enhances survival of glutamate-treated neuronal/glial cells by modulation of Ras/NF-kB signaling and reactive oxygen species. Journal of Neuroscience Research 79:224–230, 2005.
  20. Shanshiashvili L.V., Suknidze N.Ch., Machaidze G.G., Mikeladze D.G.  Ramsden J.J. Adhesion and clustering of charge isomers of myelin basic protein at model myelin membranes. Archive Biochemistry and Biophysics., 419, 170-177, 2003.
  21. Machaidze G.G., Mikeladze D. Different effects of lectins on the ligand binding of the NMDA receptors and sigma sites in rat brain hippocampus synaptic membranesNeurochemical Research, 2001, 26, N5, 457-462.

Books

  • Mikeladze “Biochemistry”, Handbook, 2007
  • Articles in magazines
  • Articles in newspapers
  • An extensive list of publications

Current Courses

Course Catalog

  • Intoductory course “ Molecules of Life and Life of molecules”
  • Bachelor course “ Biochemistry”
  • Master courses: “Molecular Pharmacology”, “Molecular Endocrinology”
  • Doctoral courses: “Principles of metabolism regulation”, “Mitochondrial dysfunctions”

Academician of Georgian National Academy of Sciences, Vice-editor of „Journal of Biological Physics and Chemistry”, member of Editorial Board of Journal “Bioenergetics – Open access”, member of Georgian Neuroscience Association, member of Georgian Association of Biochemistry, member of IBRO (International Brain Research Organisation), member of ESN (European Society for Neurochemistry) and ISN (International Society for Neurochemistry)

Personal website
https://scholar.google.com/citations?user=U9M9M7g6jnkC&hl=en&oi=ao

https://www.researchgate.net/profile/David_Mikeladze/stats/publication_downloads?date=2015-06-21