School of Natural Sciences and Engineering, Associate Professor of molecular Pharmacology

Institute of Chemical Biology

Tamar Barbakadze was born in Tbilisi in 12.09.1978. In 1995 she entered Tbilisi State University Faculty of Biology and Medicine, from which she graduated in 1999 and received Bachelor degree in biology, qualification of teacher of biology and chemistry. In 2001 Tamar received Master degree in Biology. In 2001-2004 she was PhD student at the department of biochemistry, at   the Institute of Physiology of Georgian Academy of Sciences in Tbilisi. Tamar received her candidate of science degree in biology (biochemistry) at the Institute of Biochemistry and Biotechnology, Tbilisi, Georgia. She has continued research at the Institute of Physiology (2004 to present). Scince 2009 to 2013, she was an assistant professor and from 2013 at present associate professor of Ilia State University and  research scientist of I. Beritashvili Center of Experimental Biomedicine.

Scientific interests / research interests

  • The field of her scientific interests is biochemistry and molecular biology of animals and human. The main interest is investigation the metabolism of the neuronal cells, research the the regulatory systems of nerve cells and the molecular basis of Neuropathology.
  • Her research interests are in the areas of the biochemistry of nerve cells regulation and mitochondrial bioenergetics. She studies the metabolic imbalance of immune cells during genetic diseases, in particular during cystic fibrosis. The one of the research interests of Tamar Barbakadze is the action of hypoxia on Ras-proto-oncoprotein redistribution in the neuronal cell.

Featured publications
1. Sopiko Koriauli, Tamar Barbakadze, Nino Natsvlishvili, Nino Dabrundashvili, Eka Kvaratskhelia, David Mikeladze. IL-10 Gene Knockout Reduces the Expression of mGlu Receptor 1a/b and Decreases the Glutamate-Dependent Production of Nitric Oxide, Journal of biomedical science and engineering 11/2014; 7(13):1019-1029.
2. Barbakadze T, Natsvlishvili N.,Mikeladze D. Thyroid hormones differentially regulate phosphorylation of ERK and Akt via integrin αvβ3 receptor in undifferentiated and differentiated PC-12 cells. Cell Biochemistry and Function 04/2014; 32(3)
3. Bátor J, Varga J, Berta G, Barbakadze T, Mikeladze D, Ramsden J, Szeberényi J. “Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein”. Cell Mol Biol Lett. 2012 Sep;17(3):323-32. 2012 Apr 10.
4. Zhuravliova E, Barbakadze T, Jojua N, Zaalishvili E, Shanshiashvili L, Natsvlishvili N, Kalandadze I, Narmania N, Chogovadze I, Mikeladze D. “Synaptic and non-synaptic mitochondria in hippocampus of adult rats differ in their sensitivity to hypothyroidism”. Cell Mol Neurobiol. 2012 Nov;32(8):1311-21.2012 Jun 17.
5. Shanshiashvili LV, Dabrundashvili N, Natsvlishvili N, Kvaratskhelia E, Zhuravliova E, Barbakadze T, Koriauli S, Maisuradze E, Topuria T, Mikeladze DG. “mGluR1 interacts with cystic fibrosis transmembrane conductance regulator and modulates the secretion of IL-10 in cystic fibrosis peripheral lymphocytes”. Mol Immunol. 2012 Jul;51(3-4):310-5. 2012.03.029. Epub 2012 Apr 18.
6. Shanshiashvili L, Narmania N, Barbakadze T, Zhuravliova E, Natsvlishvili N, Ramsden J, Mikeladze DG. “S-nitrosylation decreases the adsorption of H-Ras in lipid bilayer and changes intrinsic catalytic activity”. Cell Biochem Biophys. 2011 Apr;59(3):191-9.
7. Barbakadze T, Zhuravliova E, Sepashvili M, Zaalishvili E, Ramsden JJ, Bátor J, Szeberényi J, Mikeladze D. Production of homocysteine in serum-starved apoptotic PC12 cells depends on the activation and modification of Ras. Neurosci Lett. 2005 Dec 31;391(1-2):56-61.
8. Juravleva E, Barbakadze T, Mikeladze D, Kekelidze T., Creatine enhances survival of glutamate-treated neuronal/glial cells, modulates Ras/NF-kappaB signaling, and increases the generation of reactive oxygen species. J Neurosci Res. 2005 Jan 1-15;79(1-2):224-30.
9. Barbakadze T., Zhuravliova E., Kharebava G., Chatirishvili N., Dabrundashvili N., Mikeladze D. Placental peptide p6 reduce glutamate-dependent neurotoxicity. Proceedings of Georgian Acadamy of Sciences, Biological Series_A, 2004; 30:
10. Juravleva E, Barbakadze T, Natsvlishvili N, Kekelidze T, Mikeladze D. Creatine prevent the cytotoxicity of haloperidol by alteration of NO/Ras/NF-kB system. in Creatine kinase and brain energy metabolism. Creatine Kinase and Brain Energy Metabolism. Function and disease; T.Kekelidze, D. Holtzman, Ed-s., IOS Press, NATO Science Series 2003; 342: 113-121

An extensive list of publications

Current Courses

Course Catalog

  • Pharmacogenomics, Toxicogenomics and Drug Resisance Mechanisms –2014-2015 Spring semester, master’s level
  • Bioenergetics – 2014-2015 Fall/Spring semester, bachelor’s level
  • Molecules of Life and Life of Molecules – seminars, 2014-2015 Fall/Spring semester, bachelor’s level
  •  Metabolism of Medicines and Pharmacokinetics – 2014-2015 Fall semester, Master’s level
  •  Molecular Endocrinology and Molecular Mechanisms of Adaptation – 2014-2015 Fall semester, Master’s level