Direction: Neurophysiology
Position:Full Professor
Georgi Gamkrelidze graduated with a major in physiology with honors from Tbilis State University in 1988. He received Ph.D. from Moscow State University at the Physiology Department. From 1993 till 2007 he worked in the USA where he participated in three national institutes of health (NIH) funded research programs. The results of these studies he published in the leading neuroscience journals. He received postdoctoral training at Texas and George Washington universities. At these universities he studied electrophysiological membrane properties of neurons using various electrophysiological, including patch-clamp, and imaging techniques. Afterwards, he worked as a researcher at the Lucent Technology Company and New York University where he invetigated cellular and network mechanisms of the short-term memory. At the Neurology Department of the Northwestern University he held Assistant Professor position where he was investigating pathphysiology of alzheimer disease in genetically modified mice. Since 2007 Georgi Gamkrelidze works at Ilia State University and holds full professor position. At the university he lectures, supervises students and conducts research. He studies effects of myo-inositol, promising antiepileptic drug, on epileptic brain activity in rodents. During professional career Georgi Gamkrelidze has published twenty-four research articles.
Scientific interests / research interests
- Cellular mechanisms of behavior
- Ionic mechanisms of neuron excitability
- Embryonic and postnatal development of neuron excitability
- Ion channels
- Cellular mechanisms of learning and memory
- Epilepsy
- Nervous system evolution
Featured publications
Drobyshevsky A, Song S.K., Gamkrelidze G.,Wyrwicz A.M., Meng F., Derrick F., Li L., Ji X., Trommer B., Back S., Tan S. (2005). “Diffusion Anisotropy Increases Prior to the Onset of Myelination in Fetal Rabbit Brain”. J Neurosci. 25(25): 5988-5997.
Aksay, E., Gamkrelidze, G., Seung H.S., Baker, R., Tank, D.W. (2001). “In Vivo intracellular recording and perturbation of persistent activity in a neural integrator.” Nature Neuroscience. 4:184-193.
Gamkrelidze, G., Giaume C., Peusner K (2000). “Firing Properties and Dendrotoxin-sensetive sustained potassium current in vestibular nuclei neurons of the hatchling chick.” Exp. Brain Res. 134:398-401.
Gamkrelidze, G., Giaume C., Peusner K. (1998). “Differential expression of low-threshold potassium current contributes to the distinct firing patterns in embryonic central vestibular neurons.” J. Neuroscience. 18 (4):1449-1464
An extensive list of publications
Tsverava L., Kandashvili M., Margvelani G., Lortkipanidze T., Gamkrelidze G., Lepsveridze E., Kokaia M., Solomonia R. (2019). “Long-term effects of myoinositol on behavioral seizures and biochemical changes evoked by kainic acid induced epileptogenesis”. Biomed Res Int, 4518160.
Weaver C., Yadav A., Gamkrelidze G., Baker R. (2010). “Sensetivity analysis of a precerebellar neuron model predicts a morphologica mechanism for plasticity of neural function”. BMC Neuroscience, 11(1).
Weaver C., Gamkrelidze G., Baker R., Wearne S. (2007). “Sensetivity analysis enable comparison of how realistic morphology and other intrinsic properties influences neuronal firing”. BMC Neuroscience, 8 (2).
Yun S.H., Gamkrelidze G., Stine B., Sullivan P., Pasternak J., LaDu M.J. Trommer B. (2006). “Amyloid-beta 1-42 reduces excitability in mouse dentate gyrus”. Neuroscience Letters, 403 (1-2): 162-5.
Gamkrelidze G., Yun S.H., Trommer B. (2005). “Amyloid-beta as a biologically active peptide in CNS”. Chapter in Synaptic Plasticity and Transsynaptic Signaling. Eds: Stanton P.K., Bramham and Scharfman H.E.
Trommer B, Shah C., Gamkrelidze G., Yun S., Pasternak E., Stine B., Manelli A., Pasternak J., LaDu M.J. (2005). “ApoE Isoform-specific Effects on LTP: blockade by oligomeric amyloid”. Neurobiol Disease. 18(1): 75-82.
Ye G., Gamkrelidze, G., Pasternak J, Trommer B.L. (2005). “AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells”. Brain Res. Dev. Brain Res. 155(1):26-32.
Trommer B, Shah C., Yun S., Gamkrelidze G., Pasternak E., Stine B., Manelli A., Pasternak J., LaDu M.J. (2004). “ApoE Isoform affects LTP in Human Targeted Replacement Mice”. Neuroreport. 15(17):2655-2658.
Yu, B., Gamkrelidze, G., Laurienti, P., Blankenship J. (2001). “Serotonin directly increases a calcium current in swim motoneurons of Aplysia brasiliana.” American Zoologist. 41(4).
Peusner K.D., Gamkrelidze G. and Giaume C. (1998). “Potassium currents and excitability in second order auditory and vestibular neurons.” J. Neurosci. Research. 53: 511-520.
Gamkrelidze, G., Laurienti, P.J., and Blankenship, J.E. (1995). “Identification and characterization of cerebral neurons that induce swimming and modulate swim-related pedal-ganglion neurons in Aplysia brasiliana.” J. Neurophysiol. 74 (4):1444-1462.
Panchin, Y.V., Gamkrelidze G., Popova L. B., Deliagina T.G., Orlovsky, G.N. and Arshavsky Y.I. (1994). “Neuronal basis of hunting and feeding behavior in the pteropod mollusc Clione limacina.” Nether. J. Zool. 44 (3-4): 170-183.
Arshavsky, Y.I., Deliagina, T.G., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V., Popova, L.B. and Shupliakov, O.V. (1993). “Pharmacologically induced elements of the hunting and feeding behaviour in the pteropod mollusc Clione limacina. I. Effects of GABA.” J. Neurophysiol. 69: 512-521.
Arshavsky, Y.I., Deliagina, T.G., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V. and Popova, L.B. (1993). “Pharmacologically induced elements of the hunting behaviour in the pteropod mollusc Clione limacina. II. Effects of physostigmine.” J. Neurophysiol. 69: 522-532.
Arshavsky, Y.I., Deliagina, T.G., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V. and Popova, L.B. (1993). “Neurophysiological mechanism of space orientation in pteropod mollusc Clione limacina during hunting behavior.” Proc. Acad. Sci. Russia. 333:537-539.
Gamkrelidze, G. (1992). “The role of pharmacology different GABA receptors in the organization of hunting behaviour of marine mollusc Clione limacina.” Proc. Tbilisi State Univ. 56-63.
Arshavsky, Y.I., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V. and Popova, L.B. (1991). “Role of acetylcholine and gamma-aminobutyric acid in organization of feeding behaviour in pteropod mollusc Clione limacina.” Biol. Membranes. 8: 1177.
Arshavsky, Y.I., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V. and Popova, L.B. (1991). “Role of gamma-aminobutyric acid on organization of feeding behaviour of pteropod mollusc Clione limacina.” Proc. Acad. Sci. USSR. 317: 1500-1503.
Arshavsky, Y.I., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V. and Popova, L.B. (1991). “Role of acetylcholine in organization of feeding behaviour of pteropod mollusc Clione limacina.” Proc. Acad. Sci. USSR. 318: 232-235.
Arshavsky, Y.I., Gamkrelidze, G., Orlovsky, G.N., Panchin, Y.V. and Popova, L.B. (1991). “Gamma-aminobutyric acid induces feeding beharviour in the marine mollusc, Clione limacina.” NeuroReport. 2: 169-172.
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