Direction:Cell Signaling
Position:Assistant Professor
In 2002 she graduated Zugdidi Branch of Ivane Javakhishvili Tbilisi State University and obtained a Bachelor’s Degree in Biology. Then in 2004 – she gained a Master’s Degree in Molecular and Cell Biology from Ivane Javakhishvili Tbilisi State University. She defended her PhD thesis in the field of Molecular Biology in the end of 2006. Since 2007 she has worked in I.Beristashvili Center of Experimental Biomedicine (former Institute of Physiology) in Department of Biochemistry, from 2011 – at the position of Researcher in the Institute of Chemical Biology in the Ilia State University. In 2022 she became Assistant Prof of Cell Signaling, Faculty of Natural Sciences and Medicine, Ilia State University. The main field of research – signaling systems of health and cancer cells, protooncoproteins and activity of related effector molecules, posttranslational modifications, and cellular localization. Research investigation is carried out in the Institute of Chemical Biology of Ilia State University.
Scientific interests / research interests
- Changes in intracellular signaling systems during the pathologies;
- Posttranslational modifications and their effect on cellular localization;
- Protooncoproteins and regulation of their activity;
- Molecular basis of cancer transformation;
- Regulation of transcriptional activity in norm and pathology
- Featured publications
- High Mobility Group B1 Protein Secretion in Polarized Macrophages. Chikviladze M, Mamulashvili N, Sepashvili M, Narmania N, Shanshiashvili L, Mikeladze D. Bulletin of the Georgian National Academy of Sciences, 2021, 15(3), pp. 72–78
- Subcellular Distribution of S-Nitrosylated H-Ras in Differentiated and Undifferentiated PC12 Cells during Hypoxia. Barbakadze T, Goloshvili G, Narmania N, Zhuravliova E, Mikeladze D. Cell Journal (Yakhteh). 2017;19(3):443-451.
- Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism. E. Zhuravliova, T. Barbakadze, N. Jojua, E. Zaalishvili, L. Shanshiashvili, N. Natsvlishvili, I. Kalandadze, N. Narmania, I. Chogovadze, D. Mikeladze. Cell Mol Neurobiol (2012) 32:1311–1321
- S-Nitrosylation Decreases the Adsorption of H-Ras in Lipid Bilayer and Changes Intrinsic Catalytic Activity. L. Shanshiashvili, N. Narmania, T. Barbakadze, E. Zhuravliova, N. Natsvlishvili, J. Ramsden, D. G. Mikeladze. Cell Biochemistry and Biophysics 2011;59(3):191-9
- Hypoinsulinemia alleviates the GRF1/Ras/Akt anti-apoptotic pathway and induces alterations of mitochondrial ras trafficking in neuronal cells. Zhuravliova E, Barbakadze T, Narmania N, Sepashvili M, Mikeladze DG. Neurochem Res. 2009 Jun;34(6):1076-82.
- Inhibition of nitric oxide synthase and farnesyltransferase changes the activities of several transcription factors in neuronal/glial cells. Zhuravliova E., Narmania N., Barbakadze T., Ramsden J., Mikeladze D. Journal of Molecular Neuroscience 2007;31(3):281-7.
- L–NAME has opposite effects on the productions of S–adenosylhomocysteine and S–adenosylmethionine in V12-H–Ras and M–CR3B–Ras pheochromocytoma cells. Sephashvili M., Zhuravliova E., Barbakadze T., Khundadze M., Narmania N.&Mikeladze D.G. Neurochemical Research 2006, 31(10),1205-1210.
- Double modifications of Ras protein change the DNA-binding activities of transcription factors. Narmania N., Zhuravliova E., Barbakadze T., Khundadze M., Mikeladze D. Proceedings of Georgian Acadamy of Sciences, Biological Series_A, 2006 , 32(4): 815-821.
- Farnesylation and nitrosylation of p21Ras change its intrinsic GTPase activity. Narmania N., Zhuravliova E., Barbakadze T. and Mikeladze D. Journal of Biological Physics and Chemistry 2005, 5: 137–140.
Current Courses |
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Spring Semester Bachelor Courses:
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Member of Georgian Neuroscience Association (GNA), member of Georgian Biochemical Association, member of IBRO (International Brain Research Organisation), member of FENS (Federation of European Neuroscience Societies), member of FEBS (Federation of European Biochemical Societies),