Direction:Molecular Pharmacology
Position:Associate Professor
In 1979 she graduated from I. Javakhishvili Tbilisi State University, Faculty of Physics speciality of biophysics. In 1997 she received a Degree of a candidate of biological sciences at the Institute of Molecular Biology and Biological Physics of Georgian Academy of Sciences. PhD thesis – “Cloning and sequencing of the DNA-polymerase gene from archaeon Sulfolobus acidocaldarius”. She has been emploied at the Institute of Molecular Biology and Biological Physics now Ivane Beritashvili Center of Experimental Biomedicine. She has been engaged in scientific research at Engelhardt Institute of Molecular Biology (Moscow, Russia, 1993-1996), Agricultural Biotechnology Center (Godollo, Hungary, 1998) and Gent Agricultural Research Centre (ILVO, Belgium, 2004). Since 2006 has been working at Ilia State University. Main research topics: molecular study of genomes of plants, foods and genetically modified organisms (GMO); development of new DNA-diagnostics and nanotechnology methods to detect plant species and GMO.
Scientific interests / research interests
- Molecular biology and biotechnology
- Plant and food genomics
- Genetically modified plants and foods
Featured publications
- Kutateladze, T.; Bitskinashvili, K.; Sapojnikova, N.; Kartvelishvili, T.; Asatiani, N.; Vishnepolsky, B.; Datukishvili, N. (2021) Development of Multiplex PCR Coupled DNA Chip Technology for Assessment of Endogenous and Exogenous Allergens in GM Soybean. Biosensors, 11, 481. https://doi.org/10.3390/bios11120481
- Bitskinashvili K., Gabriadze I., Kutateladze T., Vishnepolsky B., Mikeladze D., Datukishvili N. (2019) Influence of Heat Processing on DNA Degradation and PCR-Based Detection of Wild Type and Transgenic Maize. Journal of Food Quality, vol. 2019, Article ID 5657640, 11 pages, https://doi.org/10.1155/2019/5657640
- Bitskinashvili K., Gabriadze I., Kutateladze T., Vishnepolsky B., Mikeladze D., Datukishvili N. (2018) Effects of thermal-acid treatment on degradation and amplification of wheat and maize DNA. Journal of Food and Nutrition Research, 57 (3) 242-251 http://www.vup.sk/en/index.php?mainID=2&navID=34&version=2&volume=0&article=2105
- Alipourfard, I., Datukishvili, N., Mikeladze D. (2019) TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes. Mediators of Inflammation. vol. 2019, Article ID 3560819, 6 pages. https://doi.org/10.1155/2019/3560819
- Datukishvili N, Kutateladze T, Gabriadze I, Bitskinashvili K and Vishnepolsky B (2015) New multiplex PCR methods for rapid screening of genetically modified organisms in foods. Front. Microbiol. 6:757. doi: 10.3389/fmicb.2015.00757 https://www.frontiersin.org/articles/10.3389/fmicb.2015.00757/full
- Gabriadze I., Kutateladze, T., Vishnepolsky, B. Karseladze, M., Datukishvili, N. (2014) Application of PCR-based methods for rapid detection of corn ingredients in processed foods //International Journal of Nutrition and Food Sciences, 3 (3), 199-202. DOI: 10.11648/j.ijnfs.20140303.21. https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=153&doi=10.11648/j.ijnfs.20140303.21
- Kutateladze, T., Gabriadze I., Vishnepolsky, B. Karseladze, M., Datukishvili, N. (2013) Development of triplex PCR for simultaneous detection of maize, wheat and soybean // Food Control, 34, 698-702. http://www.sciencedirect.com/science/article/pii/S0956713513003010
- Datukishvili, N., Gabriadze I., Kutateladze, T., Karseladze, M., Vishnepolsky, B. (2010) Comparative evaluation of DNA extraction methods for food crops //International Journal of Food Science and Technology, v. 45, 1316-1320
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2621.2010.02261.x/abstract - Datukishvili N.T., Tarkhnishvili G.M., Mikeladze D.G., Beridze T.G. Sanadze G.A. (2001) Isolation and purification of protein responsible for the conversion of dimethylallylpyrophosphate from Poplar leaves into isoprene. Russian Journal of Plant Physiology, 48, pp. 222-225.
http://link.springer.com/article/10.1023%2FA%3A1009008318764 - Datukishvili, N., Pokholok, D., Lottspeich, F., Prangishvili, D., Rechinsky, V. (1996) The DNA polymerase- encoding gene from a thermoacidophilic archaeon Sulfolobus acidocaldarius. Gene, 177, pp.271-273.
An extensive list of publications
- Kutateladze, T.; Bitskinashvili, K.; Sapojnikova, N.; Kartvelishvili, T.; Asatiani, N.; Vishnepolsky, B.; Datukishvili, N. (2021) Development of Multiplex PCR Coupled DNA Chip Technology for Assessment of Endogenous and Exogenous Allergens in GM Soybean. Biosensors, 11, 481. https://doi.org/10.3390/bios11120481
- Bitskinashvili K., Kutateladze T., Vishnepolsky B., Ninidze T., Karseladze M., Datukishvili N (2022) Analysis of Genetically Modified Maize Allergens by PCR. Bulletin of the Georgian National Academy of Sciences, v. 16 (#1): 62 – 68. http://science.org.ge/bnas/vol-16-1.html
- Bitskinashvili K., Gabriadze I., Kutateladze T., Vishnepolsky B., Mikeladze D., Datukishvili N. (2019) Influence of Heat Processing on DNA Degradation and PCR-Based Detection of Wild Type and Transgenic Maize. Journal of Food Quality, vol. 2019, Article ID 5657640, 11 pages, https://doi.org/10.1155/2019/5657640
- Alipourfard, I., Datukishvili, N., Mikeladze D. (2019) TNF-α Downregulation Modifies Insulin Receptor Substrate 1 (IRS-1) in Metabolic Signaling of Diabetic Insulin-Resistant Hepatocytes. Mediators of Inflammation. vol. 2019, Article ID 3560819, 6 pages. https://doi.org/10.1155/2019/3560819
- Alipourfard I., Datukishvili N., Bakhtiyari, S., Haghani, K., Di Renzo L., Costa de Miranda, R., Mikeladze D. (2019) MIG1 Glucose Repression on Metabolic Processes of Saccharomyces 1 Cereviceae: Genetics to Metabolic Engineering. Avicenna Journal of Medical Biotechnology (AJMB). vol. 11, No. 3 July-September 2019. http://www.ajmb.org/PDF/En/FullText/10377.pdf
- Alipourfard I., Bakhtiyari, S., Datukishvili N., Haghani, K., Di Renzo L., De Miranda, R.C., Cioccoloni, G., Basitatyan Yadi P., Mikeladze D. (2018) Saccharomyces cerevisiae, key role of MIG1 gene in metabolic switching: putative fermentation/oxidation. Journal of Biological Regulators & Homeostatic Agents, vol. 32, no. 3, 649-654.
- Bitskinashvili K., Gabriadze I., Kutateladze T., Vishnepolsky B., Mikeladze D., Datukishvili N. (2018) Effects of thermal-acid treatment on degradation and amplification of wheat and maize DNA. Journal of Food and Nutrition Research, 57 (3) 242-251 http://www.vup.sk/en/index.php?mainID=2&navID=34&version=2&volume=0&article=2105
- Datukishvili, N., Kutateladze, T., Gabriadze I., Bitskinashvili, K., Karseladze M., (2018) DNA-based approaches for reliable detection of genetically modified ingredients in processed foods, Chapter 4 in Book “Systemic, Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders” (Proceedings of I. Beritashvili Center for Experimental Biomedicine ¬ 2018), pp. 43-52, Nova Science Publishers, Inc., New Yourk, USA. ISBN: 978-1-53614-396-6 (eBook)
- Kutateladze, T., Gabriadze I., Vishnepolsky, B., Karseladze M., Datukishvili, N., (2016) Detection of genetically modified organisms by multiplex PCR, Chapter 9 in Book “Systemic, Cellular and Molecular Mechanisms of Physiological Functions and Their Disorders” (Proceedings of I. Beritashvili Center for Experimental Biomedicine ¬ 2015), pp. 85-93, Nova Science Publishers, Inc., New Yourk, USA, ISBN: 978-1-63484-988-3
- Datukishvili N, Kutateladze T, Gabriadze I, Bitskinashvili K and Vishnepolsky B (2015) New multiplex PCR methods for rapid screening of genetically modified organisms in foods. Front. Microbiol. 6:757. doi: 10.3389/fmicb.2015.00757 https://www.frontiersin.org/articles/10.3389/fmicb.2015.00757/full
- Gabriadze I., Kutateladze T., Vishnepolsky B., Karseladze M., Zaalishvili T., Datukishvili N.,
Muskhelishvili G. (2015) Polymerase Chain Reaction Based Assays for Specific Detection of Barley. Bulletin of the Georgian National Academy of Sciences, v. 9 (1), pp. 145-150
http://science.org.ge/old/moambe/9-1/Gabriadze.pdf - Gabriadze I., Kutateladze, T., Vishnepolsky, B. Karseladze, M., Datukishvili, N. (2014) Application of PCR-based methods for rapid detection of corn ingredients in processed foods //International Journal of Nutrition and Food Sciences, 3 (3), 199-202. DOI: 10.11648/j.ijnfs.20140303.21. https://www.sciencepublishinggroup.com/journal/paperinfo?journalid=153&doi=10.11648/j.ijnfs.20140303.21
- Kutateladze, T., Gabriadze I., Vishnepolsky, B. Karseladze, M., Datukishvili, N. (2013) Development of triplex PCR for simultaneous detection of maize, wheat and soybean // Food Control, 34, 698-702. http://www.sciencedirect.com/science/article/pii/S0956713513003010
- Kutateladze, T.V., Gabriadze, I.I., Datukishvili, N.T., Karseladze, M.V., Zaalishvili, T.M. (2013) Screening of genetically modified plants by duplex PCR // Annals of Agrarian Science, v. 11, n. 1, pp. 76-79.
- Datukishvili N., Kutateladze, T., Gabriadze, I., Vishnepolsky, B., Karseladze, M., Solomia, R. //Multiplex nanotechnology for genetically modified organisms control // International Scientific-Practical conference “Innovative technologies for secure and sustainable development of the agrarian sector”, Conference proceedings pp. 80-83, Tbilisi, Georgia, 3-4 October, 2013.
- Bitskinashvili, K., Gabriadze, I., Datukishvili, N. //Polymerase chain reaction based technology to study the thermal degradation of wheat DNA// International Scientific-Practical conference “Innovative technologies for secure and sustainable development of the agrarian sector”, Conference proceedings pp. 62-64, Tbilisi, Georgia, 3-4 October, 2013.
- Datukishvili, N., Gabriadze I., Kutateladze, T., Karseladze, M., Vishnepolsky, B. (2010) Comparative evaluation of DNA extraction methods for food crops //International Journal of Food Science and Technology, v. 45, 1316-1320
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2621.2010.02261.x/abstract - Kutateladze T, Karseladze M., Gabriadze I., Datukishvili, N. (2009) Optimisation of DNA-based Screening Methods for Genetically Modified Organisms // Journal of Biological Physics and Chemistry, V. 9 (2), 73-76.
- Datukishvili, N., Kutateladze, T., Karseladze, M., Gabriadze I. (2009) Comparison of screening methods for reliable detection of genetically modified organisms // Proceedings of the Georgian Academy of Sciences, Biological Series, vol.7, N3, pp. 4-8.
- Datukishvili N., Karseladze M., Zaalishvili T., Kutateladze T. (2007) Seed testing by CaMV 35S promoter-specific PCR for detection of genetically modified organisms// Proceedings of the Georgian Academy of Sciences, Biological Series, vol.5, N2, pp. 21-25.
- Datukishvili, N., Kutateladze, T., Karseladze, M., Zaalishvili, G., Gabriadze, I., Zaalishvili, T. (2006) Evaluation of DNA extraction methods for PCR analysis of fruit seeds // Proceedings of the Georgian Academy of Sciences, Biological Series, vol.4, pp. 112-116.
- Kutateladze,T., Karseladze, M., Zaalishvili, G., Zaalishvili, T., Datukishvili, N. (2005) PCR amplification of DNA from agricultural plants and genetically modified soybean. Bulletin of the Georgian Academy of Sciences, 171, pp. 345-347.
- Datukishvili N.T., Tarkhnishvili G.M., Mikeladze D.G., Beridze T.G. Sanadze G.A. (2001) Isolation and purification of protein responsible for the conversion of dimethylallylpyrophosphate from Poplar leaves into isoprene. Russian Journal of Plant Physiology, 48, pp. 222-225.
http://link.springer.com/article/10.1023%2FA%3A1009008318764 - Datukishvili, N., Tarkhnishvili, G., Mikeladze, D., Sanadze, G. (2000) Investigation of the enzymatic mechanizm of isoprene biosynthesis. Bulletin of the Georgian National Academy of Sciences, 162, pp. 523-525.
- Datukishvili, N.,Pokholok, D., Lottspeich, F., Prangishvili, D., Rechinsky, V. (1996) The DNA polymerase- encoding gene from a thermoacidophilic archaeon Sulfolobus acidocaldarius. Gene, 177, pp.271-273.
- Datukishvili, N., Pokholok, D., Prangishvili, D., Rechinsky, V. (1995) Sulfolobus acidocaldarius DNA polymerase gene, complete cds. GenBank Database, Acc. No.U33846.
- Datukishvili, N., Nanazashvili, M., Kvantaliani, Kh., Prangishvili, D. (1992) Characterization of antibodies obtained against DNA polymerase A of archaebacterium Sulfolobus acidocaldarius. Proceedings of the Academy of Sciences of Georgia, Biological Series, vol.18, N4, pp.272-276.
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2020-2021 Year Bachelor’s level
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2018-2019 Year Bachelor’s level
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